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mutations specified The reality that, as defined beneath, CLL therapy is predicated over the existence or absence of those mutations. The present consensus is always that, apart from clonal mutations, subclonal mutations which has a variant allelic frequency ranging from 5 to ten% (and for that reason below the brink of detection by common molecular tactics) is also claimed, While Those people with a variant allelic frequency reduce than 5% must not, but there is Considerably controversy around these concerns which advice may possibly adjust Down the road.
mutations and complex kar yotype. It follows a linear evolution with the CLL clone in the recurrent acquisition of CDKN2A
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